How often do you have them? Oral administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in increased incidences of embryolethality and fetal cervicothoracic vascular and skeletal abnormalities. Intravenous administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in an increased incidence of embryolethality. Significant elevation in blood pressure, including hypertensive crisis with acute impairment of organ systems, has been reported on rare occasions in patients treated with 5-HT1 agonists, including patients without a history of hypertension. Monitor blood pressure in patients treated with Imitrex. Imitrex Tablets are contraindicated in patients with uncontrolled hypertension.
Sumatriptan is not approved for use by anyone younger than 18 years old. IMITREX STATdose System, 6 mg, containing 1 IMITREX STATdose Pen, 2 prefilled single-dose syringe cartridges, and 1 carrying case NDC 0173-0479-00. It is best to take a dose of Imitrex tablets as soon as you notice symptoms of a migraine attack. Take this medicine as soon as possible after the onset of a migraine or cluster headache or associated symptoms such as nausea, vomiting, or photophobia. Before treating headaches in patients not previously diagnosed with migraine or cluster headache or in patients who present with atypical symptoms, exclude other potentially serious neurological conditions. Imitrex Injection is contraindicated in patients with a history of stroke or TIA.
Use calendars and clocks. Techniques to stop negative thoughts. Check the expiration date on the Cartridge Pack.
Since the injection is intended to be given subcutaneously, intramuscular or intravascular delivery should be avoided. Patients should be directed to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. Pen from accidentally firing until you are ready. Patients who are advised to self-administer IMITREX Injection in medically unsupervised situations should receive instruction on the proper use of the product from the physician or other suitably qualified health care professional prior to doing so for the first time.
For patients with risk factors predictive of CAD who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of sumatriptan injection take place in the setting of a physician's office or similar medically staffed and equipped facility. Because cardiac ischemia can occur in the absence of clinical symptoms, consideration should be given to obtaining on the first occasion of use an electrocardiogram ECG during the interval immediately following IMITREX Injection, in these patients with risk factors. Such reactions can be life threatening or fatal. Different types of medicine treat different types of headaches. IMITREX Injection 1 hour after the initial injection. Serotonin syndrome is a possibly fatal syndrome that can be caused by Imitrex spray. Your risk may be greater if you take Imitrex spray with certain other medicines eg, SSRIs, SNRIs. Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms. CAD prior to receiving Imitrex Tablets. If there is evidence of CAD or coronary artery vasospasm, Imitrex Tablets are contraindicated. For patients with multiple cardiovascular risk factors who have a negative cardiovascular evaluation, consider administering the first dose of Imitrex Tablets in a medically supervised setting and performing an electrocardiogram ECG immediately following administration of Imitrex Tablets. For such patients, consider periodic cardiovascular evaluation in intermittent long-term users of Imitrex Tablets. Men get them more than women do. You usually start getting them before you're age 30. Cluster headaches may disappear completely go into remission for months or years, but they can come back without any warning. Shortness of breath; wheeziness; heart throbbing; swelling of eyelids, face, or lips; or a skin rash, skin lumps, or hives happens rarely. If it happens to you, then tell your doctor immediately. No gross overdoses in clinical practice have been reported. Injection: 6-mg single-dose vial. Ottervanger JP, Vanwitsen TB, Valkenburg HA, Grobbee DE, Stricker BHC "Adverse reactions attributed to sumatriptan - a postmarketing study in general practice.
Imitrex, IMITREX STATdose Pen, and IMITREX STATdose System are registered trademarks of the GSK group of companies. Treatment of acute cluster headache with sumatriptan. the sumatriptan cluster headache study group. Cluster headaches generally reach their full force quickly -- within 5 or 10 minutes. Feeling hot or cold, weak, or "strange" in some way. Now, I am drinking Pedialyte, in hopes of staving off the headache. And if you are like me, Never eat chocolate before bed! There were insufficient data to assess the impact of race on efficacy. clotrimazole
Figure A while you are loading the Pen. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. When did your headaches first start? Rebound headaches were a problem in my teens. When Imitrex came out I was very impressed by how effective it was. I have been using it for about 10-12 years and I am now experiencing some problems with my migraines not easing up like they used too. Also, I have began to experience "leg migraines" with my regular migraines. They only react to the statdose injection. IMITREX Injection should not be administered to patients with hemiplegic or basilar migraine. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. The use of Imitrex Tablets is contraindicated in patients with ischemic or vasospastic CAD. There have been rare reports of serious cardiac adverse reactions, including acute myocardial infarction, occurring within a few hours following administration of Imitrex Tablets. Some of these reactions occurred in patients without known CAD. Your doctor may ask you to take the first dose in the office. Overuse of drugs to treat sudden migraine attacks can sometimes lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. Tell your doctor if you need to use this medication more often, if the medication is not working as well, or if you have more frequent or worse headaches. Cluster Headache: The efficacy of IMITREX Injection in the acute treatment of cluster headache was demonstrated in 2 randomized, double-blind, placebo-controlled, 2-period crossover trials. Patients age 21 to 65 were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Headache relief was defined as a reduction in headache severity to mild or no pain. In both trials, the proportion of individuals gaining relief at 10 or 15 minutes was significantly greater among patients receiving 6 mg of IMITREX Injection compared to those who received placebo see Table 3. One study evaluated a 12-mg dose; there was no statistically significant difference in outcome between patients randomized to the 6- and 12-mg doses. Your blood pressure will need to be checked often. It is not clear whether this finding was due to an effect on males or females or both. Before you use IMITREX STATdose System your healthcare provider should show you or your caregiver how to give an injection the right way. Remove device cover; remove disposable nosepiece from foil pouch and insert into the device until a click is heard; fully press and release white button to pierce capsule. When you inject the dose, make sure the Pen stays in contact with your skin during the injection. It is important to hold the Pen against the skin for at least 5 seconds. where can you get travatan in canada travatan
Non-Site Specific: Angioneurotic edema, cyanosis, death see temporal arteritis. GlaxoSmithKline Research Triangle Park, NC 27709. Be sure to write down all your important numbers and keep them in a safe place. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Increase in Blood Pressure: Significant elevation in blood pressure, including hypertensive crisis, has been reported on rare occasions in patients with and without a history of hypertension. Sumatriptan is contraindicated in patients with uncontrolled hypertension see . Sumatriptan should be administered with caution to patients with controlled hypertension as transient increases in blood pressure and peripheral vascular resistance have been observed in a small proportion of patients. US Food and Drug Administration "Zecuity sumatriptan Migraine Patch: Drug Safety Communication - FDA Evaluating Risk of Burns and Scars. Studies 2 and 3 the onset of relief was less than 10 minutes. Headache relief, as defined by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of Imitrex Injection. Approximately 82% and 65% of patients treated with IMITREX 6 mg had headache relief and were pain free within 2 hours, respectively. IMITREX injections may have worse headaches medication overuse headache. This product is not a substitute for a proper diet. Remember that it is best to get your from healthy foods. Use lists, notes, and other helpful devices as reminders. Eye: Accommodation disorders, blindness and low vision, conjunctivitis, disorders of sclera, external ocular muscle disorders, eye edema and swelling, eye hemorrhage, eye itching, eye pain, keratitis, mydriasis, and visual disturbances. Cardiovascular: Atrial fibrillation, cardiomyopathy, colonic ischemia see Prinzmetal variant angina, pulmonary embolism, shock, thrombophlebitis. Overdose in animals has been fatal and has been heralded by convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation. It's a good idea to avoid or replacement products for several hours after taking these medicines. or other forms of nicotine can increase the side effects of ergotamines.
Imitrex tablets may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex tablets with caution. Medicines are sometimes prescribed for purposes other than those listed in Patient Information leaflets. Do not use Imitrex for a condition for which it was not prescribed. Do not give Imitrex to other people, even if they have the same symptoms you have. It may harm them. If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. All medicines may cause side effects, but many people have no, or minor, side effects. Urogenital: Rare were dysuria, frequency, dysmenorrhea, and renal calculus. After taking a sumatriptan tablet, you must wait two 2 hours before taking a second tablet. Do not take more than 200 mg of sumatriptan tablets in 24 hours. Binding to Melanin-Containing Tissues: Because sumatriptan binds to melanin, it could accumulate in melanin-rich tissues such as the eye over time. This raises the possibility that sumatriptan could cause toxicity in these tissues after extended use. However, no effects on the retina related to treatment with sumatriptan were noted in any of the toxicity studies. Other Vasospasm-Related Events: Sumatriptan may cause vasospastic reactions other than coronary artery vasospasm. Both peripheral vascular ischemia and colonic ischemia with abdominal pain and bloody diarrhea have been reported. Very rare reports of transient and permanent blindness and significant partial vision loss have been reported with the use of sumatriptan. Visual disorders may also be part of a migraine attack. Morgan DR, Trimble M, McVeigh GE "Atrial fibrillation associated with sumatriptan. The injection is intended to be given subcutaneously, and intramuscular or intravascular delivery must be avoided. Instruct patients on the proper use of IMITREX STATdose Pen and direct them to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. purchase dapoxetine no prescription needed dapoxetine
Some medicines can harm your baby. Put the Pen in the open Cartridge Pack. Sumatriptan belongs to a group of drugs called triptans. It affects a certain natural chemical serotonin that constricts blood vessels in the brain. It may also block other pain pathways in the brain. Tablets: White, triangular-shaped, film-coated, and debossed with “I” on one side and “25” on the other. Take one sumatriptan tablet whole with a full glass of water. Do not split the tablet. It is unknown if this drug passes into milk. Consult your doctor before -feeding. Imitrex spray is not approved for use in CHILDREN younger than 18 years old. Talk with the doctor. How should I store Imitrex Injection? Plot. Patients taking rescue medication were censored at 15 minutes. Side Effects List Sumatriptan-Naproxen Tablet side effects by likelihood and severity. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Do not store in the bathroom. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. Imitrex spray may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Imitrex spray with caution. generic oxcarbazepine identification
Imitrex is a prescription medicine used to treat acute migraine headaches with or without aura in adults. How should I use Imitrex Statdose sumatriptan injection? Use Imitrex spray with caution in the ELDERLY; the risk of serious side effects eg, heart problems, high blood pressure may be increased. IMITREX Injection is indicated for 1 the acute treatment of migraine attacks with or without aura and 2 the acute treatment of cluster headache episodes. See Drug Reference for a full list of side effects. Drug Reference is not available in all systems. To use Imitrex spray, remove the nasal spray unit from the plastic pack. If you are taking chewable tablets, chew the tablet thoroughly before swallowing. GSK group of companies. Sumatriptan can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine. Serious and sometimes fatal brain blood vessel problems like stroke have rarely happened with Imitrex spray. Contact your doctor at once if you have confusion, one-sided weakness, or speech or vision changes. Imitrex Injection sumatriptan succinate is a selective serotonin receptor agonist used to treat headaches. Imitrex is available as a generic drug. Initial dose: 6 mg subcutaneously, once. If symptoms recur, the dose may be repeated if at least 1 hour has elapsed since the first dose.
About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. Do not press the Blue Button yet. The vascular 5-HT 1 receptor subtype to which sumatriptan binds selectively, and through which it presumably exerts its antimigrainous effect, has been shown to be present on cranial arteries in both dog and primate, on the human basilar artery, and in the vasculature of the isolated dura mater of humans. In these tissues, sumatriptan activates this receptor to cause vasoconstriction, an action in humans correlating with the relief of migraine and cluster headache. In the anesthetized dog, sumatriptan selectively reduces the carotid arterial blood flow with little or no effect on arterial blood pressure or total peripheral resistance. In the cat, sumatriptan selectively constricts the carotid arteriovenous anastomoses while having little effect on blood flow or resistance in cerebral or extracerebral tissues. Burning, pain, or redness where the shot was given. Five controlled clinical trials 2 single attack studies, 3 multiple attack studies evaluating oral sumatriptan 25 to 100 mg in pediatric patients aged 12 to 17 years enrolled a total of 701 adolescent migraineurs. These studies did not establish the efficacy of oral sumatriptan compated to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse events in these patients appeared to be both dose- and age-dependent, with younger patients reporting events more commonly than older adolescents. This information should not be used to decide whether or not to take Imitrex tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Imitrex tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Imitrex tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Imitrex tablets. You may begin to sweat a lot, or light may bother you. Store sumatriptan at room temperature away from moisture, heat, and light. What happens if I miss a dose? Cartridge Pack out of the Carrying Case. Ottervanger JP, van Witsen TB, Valkenburg HA, Stricker BH "Postmarketing study of cardiovascular adverse reactions associated with sumatriptan. General information about the safe and effective use of Imitrex. In the controlled clinical trials assessing the efficacy of Imitrex Injection as a treatment for cluster headache Studies 4 and 5 no new significant adverse reactions were detected that had not already been identified in trials of IMITREX in patients with migraine. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. How should I use sumatriptan? generic plendil experience
Imitrex tablets are a serotonin 5-HT 1 receptor agonist "triptan". It works by narrowing blood vessels in the brain, which helps to relieve migraines. Consult your doctor or if you have questions about the ingredients in your brand. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant while using Imitrex Injection. It is unknown if Imitrex Injection will harm a fetus. Your name may need to be listed on a sumatriptan pregnancy registry when you start using Imitrex Injection. Imitrex Injection can pass into breast milk and may harm a nursing baby. Do not breastfeed within 12 hours after using Imitrex Injection. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. In a study in rats dosed daily with subcutaneous sumatriptan prior to and throughout pregnancy, there was no evidence of teratogenicity. What are the ingredients in Imitrex Tablets? Two 6-mg single-dose prefilled syringe cartridges for use with IMITREX STATdose System NDC 0173-0478-00. idop.info omeprazole
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Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice. But these medicines may not be as effective as other medicines, such as triptans. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. buy authentic podofilox
If you are taking extended-release capsules, swallow them whole. not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing. It is not known whether sumatriptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. Your name may need to be listed on a sumatriptan pregnancy registry.
IMITREX Injection or Tablets. Prompt treatment allows you to get back to your normal routine and may decrease your need for other pain medications. Certain conditions can increase your risk for problems. Headache relief, as evidenced by a reduction in pain from severe or moderately severe to mild or no headache, was achieved in 70% of the patients within 1 hour of a single 6-mg subcutaneous dose of IMITREX Injection. Headache relief was achieved in approximately 82% of patients within 2 hours, and 65% of all patients were pain free within 2 hours. innopran
This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. An autoinjector device IMITREX STATdose Pen is available for use with 4-mg and 6-mg prefilled syringe cartridges. Some MEDICINES MAY INTERACT with Imitrex tablets. If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Welch KM "Drug therapy of migraine.